Tidak ada yang lebih aku sesali dari pada penyesalanku terhadap hari dimana ketika matahari tenggelam, sementara umurku berkurang tetapi amalku tidak bertambah (Abdullah bin Mas'ud).

Rabu, 27 Januari 2010

RISIKO DIABETES MELITUS TIPE 2 PADA PEKERJA LARUT DAN SHIFT MALAM

Author :
Imil Irsal Imran ; Mirnawati

ABSTRACT

Sleep is important for humans. The design that human sleep adjusted with body’s daily rhythm was generated within the neurons of the suprachiasmatic nucleus (SCN) of the hypothalamus. Output signals through efferent neurons from the SCN modulate daily rhythms in sleep and alertness, core body temperature and secretion of certain hormones. Changes in daily rhythm can occur in late and night shift workers.

Occupation sometime demands people to work until late at night or even at all night long during the night shift works. Sleep at wrong times cause problems of gastrointestinal, immunity, reproduction system, risk to cardiovascular disease, and metabolism disorders. In a long time, psychological effect of night shift can impact to hormone secretion disorders.

Increase of body mass index (BMI) on night shift workers could decrease insulin sensitivity and changed glucose metabolism. Increase of cortisol could increase production of new glucone or gluconeogenesis. Decrease of leptin could increase appetite that develop be obesity. Increase glucose production rate and obesity were risk factors to type 2 diabetes mellitus.

Diabetes mellitus is group of metabolic disease that can’t be cured clearly. Therefore, preventions are needed for late and night shift workers. Preventions can be done with resetting biology time, changing work schedule, and conducting primary prevention measures against diabetes mellitus.

Keyword: sleep, daily rhythm change, late and night shift workers, hormone secretion disorders, diabetes mellitus, prevention

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